I used Adguard (latest nightly 3.0, but I think it doesn't matter) and Opera stable on Android.
I discovered, that traffic from HTTPS websites is not filtered, for example adguard doesn't remove social widgets, and this works fine on Chrome.
I tried to change apps management > Opera >...
I just discovered, that when I use Adguard for Mac, browsers use HTTP instead of HTTP/2 protocol - I can see this in chrome console on network tab.
Question is, why? It slows down page loading because of many, many advantages with HTTP/2.