I have a problem with my Adguard for Mac on Mac Monterey (Public Beta 3). In Safari Adguard when it is running it blocks every webpage. On opening any web it starts leading then stops and never opens. On quitting Adguard Safari works well.
Adguard is currently incompatible with Apple's Private Relay. You'll need to go to System Preferences and click on Apple ID. Then uncheck Private Relay. Adguard will work after that.