I prefer the application myself because i can switch browsers and know that ads are going to be blocked instantly without me having to install another extension or having to re-enter all my codes, it also supports https (unlike admuncher that costs more), can block ads in applications (though ive not tried this and its not fully supported yet) i also prefer it as its easier to edit my codes.
basically i just prefer the application because its easier to manage and sort things out, plus if you wanted to you could add a password and use it to block off sites and probably links that kids might click to buy premium items in games.
I'm already using Adguard, and it is superior. I'm using IE 11 (what?) and it is the only way to block ads without installing extensions. I also appreciate that multiple browsers can be used ad-free. I jump back and forth because none can outweigh the other.